Stock Market - Cannabis Giants Prepare For The First “4/20 Holiday” Since The Farming Bill And Canada’s Legalization. |
- Cannabis Giants Prepare For The First “4/20 Holiday” Since The Farming Bill And Canada’s Legalization.
- Dow gets a lift from report that Boeing 737 Max software upgrade found 'operationally suitable'
- China is negotiating an important trade deal with the EU.
- CSCO
- China’s stock markets are up more than 30 percent so far this year.
- $SODE Sees Boost In Volume As Bitcoin Surges Past 5200
- what stock on nyse would make a good investment ? entertainment/internet services / healthcare/pharma/advanced manufaturing etc
- Tackle Trading Halftime Report Apr 17th 2019
- Why I am buying Intel
- $VERB Announces Closing of Sound Concepts Acquisition
- NASH DD
- AMD?
- TTMI - Above SMA 50 by >10%, just broke through March AND November resistance lines, big volume increase
- Teum
| Posted: 17 Apr 2019 06:09 AM PDT | ||
| Dow gets a lift from report that Boeing 737 Max software upgrade found 'operationally suitable' Posted: 17 Apr 2019 06:30 AM PDT | ||
| China is negotiating an important trade deal with the EU. Posted: 17 Apr 2019 06:31 PM PDT Everyone is following the trade negotiations between America and China, but recently there was a breakthrough in the discussions between China and Europe. China agreed to engage with Europe to amend the policy where Western companies are forced to share technology with China as a cost of doing business in the nation. China has leveraged its large market to get Western technology which is then used by Chinese companies to undercut Western competitors. If China wants to enter the next stage of its development, it needs to play fair and have freer markets. The steps with the EU were only the first ones. China and the EU aim to conclude their investment agreement in 2020 where China will have open markets and it will end discrimination against foreign investors. Therefore, China is working through long term issues on trade and the freeness of its markets along with the short term issues of the cyclical economy. [link] [comments]  | ||
| Posted: 17 Apr 2019 09:41 AM PDT I'm not a professional investor by any means but I have some stock in Cisco. I just checked on them after some time and it looks like they're doing stupid awesome. Am I wrong? [link] [comments]  | ||
| China’s stock markets are up more than 30 percent so far this year. Posted: 16 Apr 2019 10:22 PM PDT China's stock markets have been on a tear so far this year, amid optimism about a possible trade deal with the U.S. and hopes that the economy may be bottoming out. As of Tuesday's close, the Shanghai composite has skyrocketed more than 30 percent since its last close in 2018. The Shenzhen component has also seen massive gains of more than 40 percent in the same period. The CSI 300, which tracks the largest companies listed on the mainland, has similarly jumped beyond 35 percent. In comparison, the Dow Jones Industrial Average and S&P 500 have risen more than 13 percent and 15 percent, respectively. Last year, Chinese markets experienced their worst performance in a decade, with the Shanghai composite ending 2018 approximately 24.6 percent lower than the previous year. Beijing on Wednesday reported better-than-expected economic growth for the first quarter of 2019 — a move that could lift market sentiment even higher. The latest GDP numbers showed the world's second-largest economy grew 6.4 percent year-on-year in the first three months of this year, topping the 6.3 percent that analysts polled by Reuters had expected. A slew of recent data — compiled privately and from official sources — have also pointed to an improvement in the Chinese economy, thanks in part to Beijing's raft of stimulus measures. In March, China reported export numbers that topped estimates, and manufacturing activity that unexpectedly grew. I think the data, both in the economy and the corporate sector, is going to be pretty important to convince investors in China to come back into the market. Tai Hui J.P. MORGAN ASSET MANAGEMENT Meanwhile, Beijing appears to be close to striking a trade deal with Washington, following a series of punitive tariffs that both economic giants slapped on each other in 2018. Chinese negotiators made unprecedented proposals on forced technology transfers, a sticking point in the talks, Reuters reported in late March. But U.S. Treasury Secretary Steven Mnuchin said Monday the two sides still have lots of work ahead of them. Investors have been increasingly optimistic that a deal could be struck between the two economic powerhouses that would end their protracted trade fight. Looking ahead, one strategist said economic numbers and corporate sentiment need to improve in the next six months or so.
Source: https://www.cnbc.com/2019/04/17/china-stock-markets-soar-in-2019.html [link] [comments]  | ||
| $SODE Sees Boost In Volume As Bitcoin Surges Past 5200 Posted: 17 Apr 2019 09:39 AM PDT | ||
| Posted: 17 Apr 2019 02:51 PM PDT
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| Tackle Trading Halftime Report Apr 17th 2019 Posted: 17 Apr 2019 09:40 AM PDT There were a lot of earnings beats to start off the season, but the market doesn't seem to be responding. Come get the Coaches take over on the Halftime Report. $NFLX $IBM $CSX $UAL $MS $ABT $PEP #HTC #TeamTackle [link] [comments]  | ||
| Posted: 17 Apr 2019 01:16 PM PDT Currently, Amazon is one of the leading contenders for an up to $10 billion contract to build a private cloud for the Department of Defense. Moreover, Amazon accounts for 34% of the service sectors cloud infrastructure. Which I assume is going to get bigger in the near future. Now as for this contract, I think a company such as Amazon has a winning chance at this contract not to mention in 2013 Amazon won a $600 million with the CIA. Now, who builds these servers? Intel does Here are my sources: [link] [comments]  | ||
| $VERB Announces Closing of Sound Concepts Acquisition Posted: 17 Apr 2019 11:21 AM PDT https://www.otcmarkets.com/stock/VERB/news/story?e&id=1334188 HOLLYWOOD, Calif., April 17, 2019 (GLOBE NEWSWIRE) -- VERB Technology Company, Inc. (NASDAQ: VERB) ("VERB"), a leader in business-focused interactive video, and the pioneer of Augmented Sales Intelligence software, announces that it has completed its previously announced acquisition of Sound Concepts (the "Closing"), the leading provider of sales and marketing tools and digital technology solutions in the direct sales and affiliate marketing sector. On the terms and subject to the conditions set forth in the Merger Agreement, at Closing (the "Effective Time"), each share of Sound Concepts' capital stock issued and outstanding immediately prior to the Effective Time (the "Sound Concepts Capital Stock") was cancelled and converted into the right to receive a proportionate share of $25,000,000 of value payable to the Sound Concepts Shareholders through the combination of a cash payment and the issuance of VERB stock. The cash payment consisted of an aggregate of $15,000,000 (the "Acquisition Cash Payment"), which was paid using a portion of the net proceeds VERB received as a result of its recent public offering (the "Public Offering") of units that closed on April 9, 2019, which closing was announced on April 12, 2019. $4,000,000 of the Acquisition Cash Payment was immediately utilized by the Sound Concepts Shareholders to purchase an aggregate of $4,000,000 of units in the VERB Public Offering at the same price, and upon the same terms and conditions as all other investors who purchased units in the VERB Public Offering. As a result, VERB's net cash outlay in connection with the Sound Concepts acquisition was approximately $11,000,000. In addition, the Sound Concepts Shareholders were issued an aggregate of 3,194,888 restricted shares of VERB Common Stock, with a fair market value of $10,000,000. Following the closing, and continuing beyond the integration into VERB, the Sound Concepts leadership team will remain in their respective current positions under long-term employment agreements and retain their offices and existing team of approximately 90 people in American Fork, Utah. The combined VERB and Sound Concepts dev teams have already completed the integration of the VERB technology into Sound Concepts' Brightools platform, the combined marketing teams have publicly launched the new platform, and the combined sales teams have already signed, and are continuing to sign new enterprise users of the newly combined platform. "The VERB technology and the combined experience of the VERB executive team and board members, coupled with VERB's successful public offering and listing on NASDAQ, adds enormous resources that will translate into immediate and long-term value for our current and prospective customers," stated McKinley Oswald, Sound Concepts President. "From an operations standpoint, the VERB team is already having a positive impact on our business, helping us better serve our clients," stated Colby Allen, Sound Concepts SVP of Operations. "The combination of our application and the VERB interactive tagg video technology has resulted in a unique and effective product that is unmatched in the industry," stated Brycen Rhinehart, Sound Concepts SVP of Digital. "I believe any successful growth strategy must include growth by acquisition, as well as growth organically," stated Rory J. Cutaia, CEO. "With Sound Concepts, not only did we acquire a growing, profitable business, highly accretive and complementary to our own, but we acquired an extremely talented leadership team whom I'm proud to call my partners, and together with their dedicated staff, we will create long-term, sustainable value for our stockholders." [link] [comments]  | ||
| Posted: 17 Apr 2019 10:36 AM PDT Nonalcoholic Steatohepatitis NASH Market OverviewNonalcoholic steatohepatitis (NASH) is a liver disease caused by inflammation and damage brought on by the buildup of fat on the liver. A member of the nonalcoholic fatty liver diseases, NASH often causes no symptoms in those it affects and usually creates no problems. In some cases however, the buildup of fat around the liver leads to inflammation and tissue damage to the vital organ, preventing normal function. NASH can progress in patients, developing into fibrosis, cirrhosis or severe scarring of the liver which is often seen at the terminal stages of chronic liver disease. GlobalData forecasts that the NASH market will grow at a Compound Annual Growth Rate (CAGR) of 63% across the United States, United Kingdom, Japan, Germany, France, Italy, and Spain, reaching $18.3B by 2026. Amazingly, there are no current therapeutic options approved for the treatment of NASH. With the market open for the taking, many companies are partaking in the race to be the first to approval, over 55 companies to be exact. Currently, the largest segment of the NASH treatment options will derive from those benefiting patients with cirrhosis, with these treatments expected to account for over 60% of the NASH market by the 2026 mark and total sales of over $11.3B. In the 7 previously mentioned countries, the number of cases of NASH each year are expected to reach nearly 50 million by 2027, with the United States having about 50% prevalence, followed by Japan. As competition intensifies and pricing pressure from governments and society eroding sales of medicines for diabetes, rheumatoid arthritis and other previously profitable disease categories, with an over crowded field for developmental oncology therapeutics, the market and forecasters see NASH as an enormous new market for future profit that will accelerate a wave of deal making. Companies such as Pfizer are taking a look at new opportunities to continue their success and prevent diminishing returns in oversaturated markets. Disease Overview and Development The development of the disease is often argued among healthcare professionals, often both linked to factors such as obesity as well as genetic and epi-genetic predispositions. NASH has been observed to occur frequently alongside cardiovascular disease while NASH also increases coronary deposits creating a greater risk of cardiovascular events. Liver failure as the result of liver fibrosis and cirrhosis is a major result of the disease frequently creates the need of liver transplants. Liver disease in patients with NASH is the third leading cause of death in the patient population, while the leading cause of death is hepatocellular carcinoma, a lethal form of cancer. When deciphering when NAFLD becomes NASH, there is a score system in place dubbed the NAS score which was proposed for untreated patients based on histological analysis of liver biopsy and judged upon steatosis, lobular inflammation, and ballooning or cell degeneration. If a patient receives at least one count in each of the three categories or scores a 3 out of 8 total, the patient is considered NASH positive. One consequence of NASH is the development of liver fibrosis which is measured by a fibrosis score that goes from F0 (no fibrosis) to F4 (cirrhosis). The levels range from Type 1 being NAFL with steatosis alone, Type 2 being NAFL with steatosis plus inflammation, Type 3 being NASH with steatosis plus hepatocyte injury or ballooning, and Type 4 being NASH with steatosis plus fibrosis. After Type 4, the liver develops full cirrhosis. In the end, experts don't know why some people with a buildup of fat in the liver get NASH and some don't. It could be that something in the environment triggers the inflammation in those people. Or maybe it runs in their families. As mentioned above, there are a multitude of things that put people at risk for NASH and for liver damage including: Obesity. *Insulin resistance and type 2 diabetes. *High cholesterol and high triglycerides. *Metabolic syndrome. *Genetic and Epi-genetic disposition The continual increase of obesity in the western world and occurrence of type 2 diabetes along with high fat diets is going to continue to drive NASH. As the aging population from a fast food generation starts to mature in to their elderly years, the patient population for this disease is going to be startling. A majority of the patient population of NASH are 40 to 50 years old and have one or more of the problems listed above. Yet NASH can happen in people who have none of these risk factors and show no symptoms. A majority of patients report feeling fine and having never known of the disease manifestation. Common symptoms that appear as NASH progresses include fatigue, weight loss, general weakness, and aches around the liver and stomach. It is often years into the disease when NASH becomes severe that individuals begin to notice the symptoms and it is often too late. Off-Label (Supportive Therapies) Drugs for NASH Treatment Considering the market outlook, the number of treatment options for NASH is likely to increase significantly with the amount of research being poured into the disease, while the supportive therapies or off-label market share will begin to decrease from its recent peak of 100% in 2016 to 11% in 2027. Unmet Need Now, there is no approved therapy for the NASH treatment, causing several companies to divert their focus towards the development of targeted drugs with novel mechanism of action in the treatment of this disease. Patients with NASH are associated with a 50% higher chance of death than those patients diagnosed with just NAFLD, according to a recent study. Competition in NASH With the recent failure from Gilead, whose NASH drug trial STELLAR-4 did not achieve its primary endpoints, the race for FDA approval continues with tightening competition and leaders. I believe that first to market with this product will be crucial to success in the field over the next 2-3 years. While other drug candidates may see approval, a majority of patients will likely be dosing the first to market product to treat their debilitating disease. As over 50 different companies are moving to find the best treatment, there are several standouts who appear to be potential winners for both patients and investors. Here I am going to cover 4 different companies drug candidates handling NASH and a quick synopsis of their market position in timing and financials. From the early looks of things, we seem to have a winner. Intercept Pharmaceuticals Recently, Intercept Pharmaceuticals announced additional positive data from their REGENERATE Phase III study, which just so happens to be the very first successful Phase III study completed on patients with liver fibrosis due to NASH. With intentions to file for regulatory approval in not only the United States, but Europe as well in the second half of 2019, the recent dip in share price appears to be a tempting opportunity. Intercept focused on the study of obeticholic acid (OCA) in patients with liver fibrosis due to NASH. Once daily OCA dosed at 25 mg met primary endpoint in improving fibrosis of the liver with no worsening in NASH diagnosis through an 18-month analysis. It is important to note however, that there were two separate arms in the NASH study, with only one of the two meeting the endpoint. Based on a previously established agreement with the FDA, only one of the two endpoints was needed to conclude a successful trial. The primary efficacy analysis assessed efficacy at 18 months in 931 patients with stage 2 or 3 liver fibrosis due to NASH. There were fairly low levels of study discontinuation throughout the population which was nearly identical across both arms and placebo in the study: 16% in placebo, 17% in OCA 10 mg and 15% in OCA 25 mg. An additional pre-specified full efficacy analysis at 18 months added an exploratory cohort of 287 NASH patients with stage 1 liver fibrosis and additional risk factors who were at increased risk of progression to cirrhosis (N=1,218). Safety of the drug trial was done across 1,968 randomized patients who received a minimum of one dose of OCA or placebo. Adverse events were generally mild to moderate in severity and the most common were consistent with the known profile of OCA. The frequency of serious adverse events was similar across treatment arms: 11% in placebo, 11% in OCA 10 mg and 14% in OCA 25 mg. Unfortunately, there were 3 deaths in the study, yet none were considered related to treatment or the trial. The most common adverse event reported was dose-related pruritus: 19% in placebo, 28% in OCA 10 mg and 51% in OCA 25 mg. OCA treatment was found to be associated with an increase in LDL cholesterol, with a peak increase of 22.6 mg/dL at 4 weeks and subsequently reversing and approaching baseline at month 18, which happened to be consistent with previous trials and data with on OCA. Triglycerides rapidly and continually decreased in the OCA treatment arms through month 18. There was an associated risk of higher incidence of gallstones or cholecystitis in OCA 25 mg patients compared to 10 mg and placebo patients. More recently, Intercept announced that they provided additional positive data to backup their already successful Phase III study. Roughly three times as many patients in the OCA 25 mg group achieved an improvement of fibrosis by ≥2 stages compared to placebo (13.3% vs 4.5%; p=0.0008). In fibrosis by ≥1 stage, approximately three times as many patients in the OCA 25 mg group improved versus worsened at 38.0% vs 13.1%, while in contrast the placebo group saw 23.2% vs 20.9% respectively. Substantially more patients in the OCA 25 mg group achieved improvements in the key underlying features of NASH, including hepatocellular ballooning, lobular inflammation and normalization of alanine aminotransferase at baseline achieved compared to those in the placebo group. The company ended 2018 with a strong cash position of roughly $436.2 million and saw revenues of $177.8 million from Ocaliva, which is expected to reach approximately $240 million this year. The company does have a rather high burn rate however, producing a loss of $309.2 million throughout the year, which is actually a nearly 20% improvement on the loss the previous year. I expect that towards the end of 2019 and into 2018 Intercept will look to do a raise to help marketing their flagship NASH product as well as expand on their distribution channels of Ocaliva. With the NASH study coming to an end, the expenses are just transferring. Like I said, in the NASH space, first to market will be key. Intercept is clearly on their way. There are a few hurdles left in place, but the recent drop in price signals a buy to me. Will only one endpoint be the cause of no approval despite agreement by the FDA? Madrigal Pharmaceuticals What can I say, I love Madrigal Pharmaceuticals. You can review my synopsis and run down of the company through my post history. While I won't use this portion to rehash what I have already written about the company, I will be expanding on their initiation of their Phase III study on multinational, double-blind, randomized, placebo-controlled MGL-3196 in patients with NASH and fibrosis to resolve NASH and reduce progression of cirrhosis. The study will utilize biopsy confirmed NASH with stage 2 or 3 fibrosis and receive a placebo, 80 mg, or 100 mg dose of resmetirom. A second liver biopsy will be taken at the end of 1 year from first dose in the first 900 patients treated to determine if the endpoint of whether resmetirom shows a significant difference in hepatocyte ballooning, lobular inflammation, and no worsening of the fibrosis stage. The company will also be focusing on reducing in LDL-cholesterol and improvement in fibrosis stage by 1-point or more at the 52-week mark. The study will continue for a total of 54 months. Looking at Phase II of the study, the CEO of Madrigal was quoted, "In Phase 2, 25% of all resmetirom treated patients, and 37% of treated patients who were on adequate doses of resmetirom, achieved the Phase 3 NASH resolution endpoint (NASH resolution with at least a 2-point reduction in NAS and no fibrosis stage worsening); both results demonstrated statistically significant differences relative to placebo." One key difference in Phase III is the increased dosing of patients. It is hoped that the higher doses might prove more effective than those in Phase II, as the higher dose in the concluded phase did show higher efficacy. As you might know, MGL-3196 has been proven to be quite the contender for treating NASH, showing efficacy and tolerability through a majority of patients. I have been in this company for many months now, and am very confident in them. I am concerned however with Intercept Pharmaceuticals getting approval within the year, while Madrigal Pharmaceuticals still has many months before their Phase III study is concluded. I will say, Madrigal is my favorite and pick. This current price level, far off its recent highs, is more than attractive to entice me to continue buying. Viking Therapeutics Viking therapeutics has been the hot topic of conversation when NASH is involved among many retail traders and investors. I believe that this is mainly due to the low entry point, people believe that it is poised to rocket the same way that Madrigal had upon positive data. Whether this is the actual case, I am not sure. I do know however that the stock tends to run off great news, showing signs of high volatility. Let's take a look. Viking Therapeutics' novel drug VK2809 is a selective thyroid hormone receptor beta agonist which has a high selectivity for liver tissue which suggests treatment for metabolic disorders such as NASH. The company presented an in vivo model in mice of glycogen storage disease at a conference last October showing that VK2809 led to overall improvement in liver health by restoration of autophagy, reduction in steatosis, reduction of inflammation and liver size. All of these positive outcomes pointed to the conclusion that VK2809 is a potential candidate for the treatment of NAFLD and NASH. Further, the company presented results from their Phase II study of VK2809 in patients with NAFLD and elevated LDL-cholesterol at the 12-week point, demonstrating achievement of both primary and secondary endpoints. The primary endpoint was the statistically significant reduction of LDL-cholesterol compared to a placebo. The company demonstrated this reduction of LDL-C at both every day and every other day dosing. The company's secondary endpoints of reducing liver fat content at 12 weeks of treatment was extremely successful, with over 90% of patients demonstrating a greater than 30% reduction in liver fat content in just 3 months. The company just provided an update on their Phase II data, demonstrating that 100% of patients receiving 5 mg of VK2809 dosed daily were experiencing more than 30% reduction from baseline in liver fat content at week 12. Now THAT is statistically significant. I think one of the biggest notes to make about this company is the $302 million in cash as of the end of 2018 that the company has will allow them to operate through 2021 at a minimum. This is an uninterrupted 2 years of cash runway. No fear of dilution or offerings in the near future, which for a smaller market cap company like Viking Therapeutics, is massive. Phase IIb of the study is set to initiate in the second half of 2019, making this year a key year for Viking. The company only needs to continue Phase II to completion and obtain liver biopsies of their patients. Having patients with no confirmed NASH through biopsies is a hurting point for the company. I believe once they make that step and continue positive results, they can easily see similar gains as Madrigal had. However hopeful I am for Viking, I remain realistic. I am debating on adding some to my portfolio in the near future when news starts to die and the price begins to pullback as I know this is a high volatility stock. The downsides listed above are coupled with the fact that this company is still likely 6+ years away from approval. Definitely a downer. Other Notable Contenders (listed favorite first): *GENFIT's Elafibranor *Allergan's Cenicriviroc *Galectin's Belapectin [link] [comments]  | ||
| Posted: 17 Apr 2019 10:08 AM PDT I've been an AMD holder for a while now, and I'm genuinely confused as to why the stock is lower today. Sony just announced that it picked AMD again as the chip maker for the their next consoles. They are rapidly cutting into Intel's market share because of Intel's struggle to keep up with demand, and their Ryzen GPU sales has been really strong. They will be releasing their earnings report on the 30th and from what analysts are saying, its going to be high. So what gives? Intel announces they wont be doing 5G anymore and their stock goes up? Am i missing something? [link] [comments]  | ||
| Posted: 17 Apr 2019 09:44 AM PDT | ||
| Posted: 17 Apr 2019 06:02 AM PDT Any thoughts recently got in with a very small position thinking about upping it have friends that think it will be in the high teens by next year [link] [comments]  |
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